ABSTRACT The Pancreas, a vital organ due to its production of digestive enzymes and regulatory hormones, can be affected by various endocrine and exocrine diseases, including cancer. Pancreatic cancer (PC), which has the lowest 5-year survival rate of approximately 10% among major organ tumors, is an aggressive, late-diagnosed, poor-prognosis type of cancer. PC typically remains asymptomatic until the advanced stage in most patients, making it challenging to reheat. Surgery remains the sole treatment modality with the potential for curative outcomes; however, it is applied only to a small percentage of patients. The risk of PC has been affirmed due to the rise in daily cigarette consumption and smoking duration, whereas quitting smoking yields the contrary effect. Moreover, factors such as higher body mass index, longer-term obesity, history of pancreatitis, excessive alcohol consumption, diabetes, and impaired fasting glucose are all linked to an increased risk of PC. Increasing awareness of genetic predisposition and avoiding such risk factors may significantly help in reducing this disease’s prevalence in society. In addition to conducting extensive research on treatment options, studying modifiable risk factors that help limit PC development is crucial. This review examines recent studies on these risk factors and evaluates their distribution in Turkey. Our analysis suggests—even when other factors are not considered—that the rising rates of obesity, diabetes, and smoking (modifiable risk factors) are likely to lead to an increase in the prevalence of PC in Turkey in the coming years.