ABSTRACT Aim: Streptococcus pyogenes (S.pyogenes) is the most common bacterial cause of acute tonsillopharyngitis in adults. With appropriate and rapid antibiotic treatment, the duration of the disease is shortened, complications are prevented and transmission is reduced. We aimed to determine how the first dose of intravenous (IV) amoxicillin+clavulanic acid treatment administered in our emergency department affects the course of the disease in patients diagnosed with acute tonsillopharyngitis due to S. pyogenes.